Cellectis - bioresearch

Meganuclease-engineering by Cellectis bioresearch.

Cellectis bioresearch mission is to democratize the power of meganuclease-driven homologous recombination for the generation of isogenic stable cell lines.

Meganucleases are endonucleases with long recognition sites. They are highly specific DNA scissors that can be used to induce DNA double-strand breaks at unique positions in a given genome.

Homologous recombination is a natural safety mechanism to conserve DNA integrity that is conserved among species and evolution. It protects chromosomes against DNA double-strand breaks by enabling the replacement of one DNA sequence by another with high precision and fidelity.

Meganuclease-driven homologous recombination combines the unique properties of meganucleases and homologous recombination to generate unique tools for efficient targeted integration of genes at given genomic positions.