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Effective tools for the in vitro evaluation of chronic hepatotoxicity

NEW Enhanced hiPS-HEP are highly homogenous populations of human iPS-derived hepatocytes. These cells are ideal for use in drug metabolism and toxicology related applications that demand a highly reproducible platform, continous supply of material and substantial expression of drug metabolism enzymes.

Enhanced hiPS-HEP (human iPS-derived cells)

Reference Format Size Quality
HEP-104-VIAL-01 Frozen 1 vial suitable for one 96-well plate >7 x 106 cells
HEP-104-0024 Fresh 24-well plate >3.3 x 106 cells
HEP-104-0096 Fresh 96-well plate >2.0 x 106 cells

Benefits

  • Long-term toxicity studies
    • stable CYP1A, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A activity for up to 8 days (post-recovery) suitable for metabolic toxicity and chronic toxicity
  • Relevant & predictive drug metabolism and toxicology data
    • human iPS-derived cells with expression of main hepatotoxicity markers
  • Reproducibility
    • low lot-to-lot variation
    • robust differentiation protocols resulting in highly homogenous population (>80% pure)
    • continuous supply of material from a consistent genetic background
  • Flexibility
    • fresh and frozen format
    • available in vial, and multi-well plate format

hiPS-HEP™ (human iPS-derived cells)
hiPS-HEPTM are highly homogenous populations of human iPS-derived hepatocytes. The cells are ideal for use in hepatocyte-related applications that demand a highly reproducible platform and continuous supply of material. Our hepatocytes will help you deliver consistent and predictable results in your long term toxicity studies.
 

hES-HEP™ (human ES-derived cells)
hES-HEPTM are highly homogenous populations of human ESC-derived hepatocytes. The cells are ideal for use in hepatocyte-related applications that demand a highly reproducible platform and continuous supply of material. Our hepatocytes will help you deliver consistent and predictable results in your long term toxicity studies.

 

Applications Typical assays
  • Drug discovery
  • Vaccine development
  • Toxicology testing
  • High Content Analysis
  • Drug-induced steatosis
  • Drug-induced phospholipidosis

 

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