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Drug Discovery

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Fast and effortless generation of stable and isogenic clones: screen a few clones only, highly stable expression

Cellectis bioresearch has developed cGPS® and cGPS® Custom targeted integration kits for the fast and effortless generation of stable and isogenic cell lines from engineered and native cell lines, respectively.

cGPS® kits are easy and ready-to-use research tools to generate isogenic and stable clones in as few as 19 days. Clones display a high genotypic homogeneity which means fewer clones to characterize than with classical stable transfection, and therefore increased productivity. A highly stable expression has always been observed for at least 45 passages even in the absence of selection agents (except for cGPS® CHO-K1 and cGPS® Duo CHO-K1 Full Kits).

Our cGPS® kits are ideal to design cell-based assays for drug screening and drug profiling.


All cell lines generated with cGPS® and cGPS® Custom Full Kits listed below can be used in a Drug Discovery process, see our Sales Terms.

cGPS Custom HepG2 Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable HepG2 isogenic clones in 36 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived HepG2 clones. Can be applied to any human derived cell line.

  • Selection of clones in 36 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more

cGPS Custom MRC-5 Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable MRC-5 isogenic clones in 27 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived MRC-5 clones. Can be applied to any human derived cell line.

  • Selection of clones in 27 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more

cGPS Custom Jurkat Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable Jurkat isogenic clones in 35 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived Jurkat clones. Can be applied to any human derived cell line.

  • Selection of clones in 35 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more

cGPS Custom K-562 Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable K-562 isogenic clones in 30 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived K-562 clones. Can be applied to any human derived cell line.

  • Selection of clones in 30 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more
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