Best TALEN™ design, thanks to over fifteen years of expertise in genome customization

The Cellectis R&D team looks back on fifteen years of experience in genome customization with sequence specific endonucleases, protein engineering and DNA repair mechanisms. Based on this know-how, we have improved and optimized TALEN™ designs to provide Custom TALEN™ Services with unparalleled expertise.

TALEN™ Hit Software

Genome coverage studies at Cellectis bioresearch using our exclusive TALEN™ Hit Software reveal a TALEN™ hit every 2 to 3 nucleotides. This great amount of potential hits is due to low context dependence.

This provides significant advances in flexibility of design and universality of use over other sequence-specific nuclease-based technologies, such as Zinc Finger Nucleases that show a limited approach to design and positioning relative to the desired mutation site.

Facilitating assessment of your sequence for a range of applications, we have made freely available a simple version of this algorithm: TALEN™ Hit Software, where you can assess your sequence for potential TALEN™ hits.

The generated hit search results do not give any indications on the best suited TALEN™ for your project but an overview of  possible TALEN™ hits in your region of interest.

Amongst this large choice of TALEN™ hits, our bioinformatics experts will identify your Custom TALEN™ based on know-how and experience in gene customization.

Examples of possible gene editing projects with TALEN™ such as gene-knock out, targeted transgene integration, nucleotide substitution, gene tagging, promoter swapping or protein truncation.

With Cellectis bioresearch Custom TALEN™ Services, all gene customization projects such as gene knock-out, gene tagging, promoter swapping and nucleotide substitution; or protein truncation, and all of your new project ideas, can be easily achieved.