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Integrate your gene of interest at a given transcriptionally active locus and achieve controlled and sustained protein expression.
Meganucleases are endonucleases with long recognition sites. They are highly specific DNA scissors that can be used to induce DNA double-strand breaks at unique positions in a given genome. Meganuclease-driven homologous recombination combines the unique properties of meganucleases and homologous recombination to generate unique tools for efficient targeted integration of genes at chosen and unique genomic positions.
We offer two-ways to efficiently integrate a gene at a given genomic position, through two lines of kits:
cGPS®: Find your way in pre-engineered cell lines
Meganucleases are natural enzymes from yeast, bacteria, algae and fungi that recognize and cleave at unique positions in the genomic DNA of their originating hosts. To use meganuclease-driven targeted integration in mammalian cell lines, a natural meganuclease recognition site is integrated in the genome of mammalian cells.
Use cGPS® pre-engineered cell lines for optimal integration efficiency.
cGPS® Custom : Customize your own cell lines
We have recently published that meganucleases can be engineered to change their recognition site sequence. This breakthrough in protein engineering alleviates the need to pre-engineer cell lines with a natural meganuclease recognition site.
You have derived a particular cell line? You have already modified it and do not wish to do the work again on a yet-to-purchase “wild-type” cell line? Customize your lab's cell line with cGPS® Custom Kits
