Cellectis - bioresearch

Customize your own cell lines
Kits for fast and effortless gene integration at a given natural locus.

Meganucleases are natural enzymes from yeast, bacteria, algae and fungi that recognize and cleave at unique positions in the genomic DNA of their originating hosts. Meganucleases induce DNA double-strand breaks that can be repaired using natural homologous recombination.

We have recently published that meganucleases can be engineered to change their recognition site sequence. This breakthrough in protein engineering alleviates the need to pre-engineer cell lines with a natural meganuclease recognition site. Engineered meganucleases achieve targeted integration on “wild type” cell lines.

• targeted gene integration in your lab’s cell line
• guaranteed gene expression
• sustained protein production
• clone homogeneity
• fast & effortless

cGPS^® Custom is the unique way to stably express a protein from your cell line!