>>> Check out now if your sequence's got talent: use our TALEN^TM  Hit^TM software.

> TALEN^TM  Services

• TALEN™ Access™ and TALEN™ First™: Production of Custom TALENs™ for all gene customization projects: to target any gene, at any position, in any genome.
• NEW!!! TALEN™ Sure KO™: TALEN™ Sure KO™ ensures gene knock-out by introducing frame shift mutations with the first coding exon of any gene.
• Custom TALEN™ Project Support: Project-specific, personalized scientific support for the highest project success.

TALENs^™ are new genome customization tools that can be used for gene-specific modifications and disruptions.

TALEs were first discovered in the plant pathogen, Xanthomonas. TALEs specifically bind to DNA and regulate plant genes during infection by the pathogen.

Each TALE contains a central repetitive region consisting of varying numbers of repeat units of typically 33-35 amino acids. It is this repeat domain that is responsible for specific DNA sequence recognition. Each repeat is almost identical with the exception of two variable amino acids termed the repeat-variable diresidues. The mechanism of DNA recognition is based on a code where one nucleotide of the DNA target site is recognized by the repeat-variable diresidues of one repeat.

TAL Effector Nucleases (TALENs^TM) are recently discovered promising tools that can be used for gene-specific modifications and disruptions, just like the zinc finger nucleases.

What are TALENs^TM?

Transcription Activator-Like Effector Nucleases (TALENs) are a novel class of sequence-specific nucleases created by the fusion of transcription activator-like effectors (TALEs) to the catalytic domain of an endonuclease.

Dan Voytas, CSO of Cellectis plant sciences, has been one of the pioneer researchers developing these tools for genome customization purposes and we, at Cellectis bioresearch, are very proud to rapidly make these tools accessible* at affordable price to the greater life sciences community.