A highly faithful repair mechanism

Homologous recombination is a natural safety mechanism that conserves DNA integrity and protects chromosomes from DNA damage such as DNA double-strand breaks (DSBs) induced by UV damage, chemical agents, etc. This recombination mechanism is well preserved throughout evolution and across species, and is an essential factor in cell survival.

cGPS^®: the cellular Genome Positioning System  revolution

cGPS^® products send your transgene to the desired destination in no time

Targeted integration corresponds to the stable genomic integration of a DNA sequence, most of the time a transgene expression cassette, at a unique genomic position. The unique genomic position has been selected to guarantee an adequate transcriptional activity.

Extensive experience in genome engineering

Cellectis bioresearch was incorporated as a subsidiary of Cellectis (Alternext: ALCLS) in June 2008, and provides life science researchers with targeted integration products based on Meganuclease-driven Homologous Recombination.