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Drug Discovery

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Fast and effortless generation of stable and isogenic clones: screen a few clones only, highly stable expression

Cellectis bioresearch has developed cGPS® and cGPS® Custom targeted integration kits for the fast and effortless generation of stable and isogenic cell lines from engineered and native cell lines, respectively.

cGPS® kits are easy and ready-to-use research tools to generate isogenic and stable clones in as few as 19 days. Clones display a high genotypic homogeneity which means fewer clones to characterize than with classical stable transfection, and therefore increased productivity. A highly stable expression has always been observed for at least 45 passages even in the absence of selection agents (except for cGPS® CHO-K1 and cGPS® Duo CHO-K1 Full Kits).

Our cGPS® kits are ideal to design cell-based assays for drug screening and drug profiling.


All cell lines generated with cGPS® and cGPS® Custom Full Kits listed below can be used in a Drug Discovery process, see our Sales Terms.

cGPS Custom HCT 116 Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable HCT 116 isogenic clones in 19 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived HCT 116 clones. Can be applied to any human derived cell line.

  • Selection of clones in 19 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more

cGPS Custom U-2 OS Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable U-2 OS isogenic clones in 26 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary derived U-2 OS clones. Can be applied to any human derived cell line.

  • Selection of clones in 26 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more

cGPS HEK-293 Duo Full Kit DD

cGPS® (cellular Genome Positioning System) technology based on meganuclease-driven homologous recombination for targeted integration in engineered cell lines. Contains two gene integration sites by combining the advantages of the cGPS HEK-293 and cGPS Custom HEK-293 kits. Ideal to develop cell-based assays with difficult to express targets. The Duo product allows working with inducible expression system and expressing multimeric drug targets. 

  • 95% of targeted integration events 
  • stable expression >12 weeks even in the absence of selection agents
more

cGPS Custom HEK-293 Full Kit DD

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines.
Enables the effortless generation of stable HEK-293 isogenic clones in 26 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory\'s proprietary derived HEK-293 clones. Can be applied to any human derived cell line.

  • Selection of clones in 26 days
  • 85% of targeted integration events
  • stable expression >10 weeks even in the absence of selection agents
more
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