cGPS® (cellular Genome Postioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines.
Enables the fast and effortless generation of stable human-derived isogenic clones. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory's proprietary human-derived clones.
This kit can be used in several human-derived cell lines and the components of the kit will vary according to the cell line you work with.
For further information regarding the application of that kit in your cell line, please email us from the contact page.
Drug Discovery
Drug Discovery
Fast and effortless generation of stable and isogenic clones: screen a few clones only, highly stable expression
Cellectis bioresearch has developed cGPS® and cGPS® Custom targeted integration kits for the fast and effortless generation of stable and isogenic cell lines from engineered and native cell lines, respectively.
cGPS® kits are easy and ready-to-use research tools to generate isogenic and stable clones in as few as 19 days. Clones display a high genotypic homogeneity which means fewer clones to characterize than with classical stable transfection, and therefore increased productivity. A highly stable expression has always been observed for at least 45 passages even in the absence of selection agents (except for cGPS® CHO-K1 and cGPS® Duo CHO-K1 Full Kits).
Our cGPS® kits are ideal to design cell-based assays for drug screening and drug profiling.
All cell lines generated with cGPS® and cGPS® Custom Full Kits listed below can be used in a Drug Discovery process, see our Sales Terms.
cGPS Custom Human Full Kit DD
cGPS HEK-293 Full Kit DD
cGPS® (cellular Genome Positioning System) technology based on meganuclease-driven homologous recombination for targeted integration in engineered cell lines. Enables the effortless generation of stable HEK-293 isogenic clones in 24 days. Ideal for robust gene functional studies and data comparisons.
- Selection of clones in 24 days
- 85% of targeted integration events
- stable expression >12 weeks even in the absence of selection agents
cGPS Custom CHO-K1 Full Kit DD
cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines.
Enables the effortless generation of stable CHO-K1 isogenic clones in 29 days. Ideal for drug screening and drug profiling in laboratory\'s proprietary derived CHO-K1 clones.
- Selection of clones in 29 days
- 90% of targeted integration events
- stable expression >12 weeks even in the absence of selection agents
cGPS CHO-K1 Duo Full Kit DD
cGPS® (cellular Genome Positioning System) technology based on meganuclease-driven homologous recombination for targeted integration in engineered cell lines. Contains two gene integration sites by combining the advantages of the cGPS CHO-K1 and cGPS Custom CHO-K1 kits. Ideal to develop cell-based assays with difficult to express targets. The Duo product allows working with inducible expression system and expressing multimeric drug targets.
- 95% of targeted integration events
- stable expression >12 weeks even in the absence of selection agents
