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Drug Discovery

Drug Discovery

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Fast and effortless generation of stable and isogenic clones: screen a few clones only, highly stable expression

Cellectis bioresearch has developed cGPS® and cGPS® Custom targeted integration kits for the fast and effortless generation of stable and isogenic cell lines from engineered and native cell lines, respectively.

cGPS® kits are easy and ready-to-use research tools to generate isogenic and stable clones in as few as 19 days. Clones display a high genotypic homogeneity which means fewer clones to characterize than with classical stable transfection, and therefore increased productivity. A highly stable expression has always been observed for at least 45 passages even in the absence of selection agents (except for cGPS® CHO-K1 and cGPS® Duo CHO-K1 Full Kits).

Our cGPS® kits are ideal to design cell-based assays for drug screening and drug profiling.


All cell lines generated with cGPS® and cGPS® Custom Full Kits listed below can be used in a Drug Discovery process, see our Sales Terms.

cGPS CHO-K1 Full Kit DD

cGPS® (cellular Genome Positioning System) technology based on meganuclease-driven homologous recombination for targeted integration in engineered cell lines.
The cGPS® CHO-K1 Full Kit enables the effortless generation of stable CHO-K1 isogenic clones in 24 days. This kit is ideal for drug screening and drug profiling and has been validated with main drug target classes. Several genes can be co-expressed from the same integration site, from identical or different promoters, allowing for expression level flexibility.

  • Selection of clones in 24 days
  • 98% of targeted integration events
  • stable expression >23 weeks even in the absence of selection agents
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