Relevant models for in vitro toxicology

Our hES-derived hepatocytes are ideal for the in vitro evaluation of hepatotoxicity delivering consistent and predictable results in your long term toxicity studies.

 

Product Information

Reference Format Size No. of cells
HEP-102-0006 Fresh 6-well plate 4.3x106
HEP-102-0024 Fresh 24-well plate 3.3x106
HEP-102-0096 Fresh 96-well plate 2.0x106
HEP-102-0T25 Fresh T25 flask 1.9x106

 

Morphology of hES-HEP™: Polygonal, single- or bi-nucleated cells containing light nuclei with distinct nucleoli.hES-HEP™ express Hepatocyte nuclear factor 4a (HNF4a), a1-antitrypsin (A1AT), Glutathione S-transferase A1 (GSTA1), and store glycogen as indicated by PAS

 

 

 

 

Table of characteristics

Morphology Polygonal cell shape, nuclei with distinct nucleoli, often bi- or multi-nucleated.
Protein Markers FOXA2
HNF4A
A1AT
CK18
CK8
GSTA1
Gene Expression CYP1A1, 1A2
CYP3A4, 3A5
CYP2C9
GSTA1
UGT2B7
MRP2
BSEP
OCT-1
A1AT
TAT
Functionality Glycogen storage
CYP1A and CYP3A activity

 

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