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Custom TALEN™
Cell engineering tools for successful gene editing projects
TALEN™ (Transcription Activator-Like Effector Nucleases) are a novel class of sequence-specific nucleases, created by fusing a transcription activator-like effector DNA binding domain to the catalytic head of an endonuclease. These nucleases allow DNA double strands breaks with very high efficiency and precision.
Available products
Custom TALEN™ is your product of choice for any gene editing projects:
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TALEN™ Basic
Your Custom TALEN™ of choice for any gene modification projects (tag genes, substitute nucleotides, swap promoters, etc.)
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TALEN™ Sure KO
Your Custom TALEN™ of choice for highest gene knock-out success with TALEN™ binding its recognition site within the first coding exon
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Compact TALEN™
Your Custom TALEN™ of choice for any gene modification or gene knock-out projects in sensitive, difficult to transfect, cell lines
How does it work?
TALEN™ (Transcription Activator-Like Effector Nucleases) are a novel class of sequence-specific nucleases, created by fusing a transcription activator-like effector DNA binding domain to the catalytic head of an endonuclease. These nucleases allow DNA double strands breaks with very high efficiency and precision.
With Custom TALEN™, select the right nuclease for your specific application and choose from our available levels of validation of TALEN™ activity or request a custom validation.
Do not hesitate to contact us to discuss your cell engineering project and to define together the best TALEN™ and validation level answering your needs.
Custom TALEN™ |
TALEN™ Basic |
TALEN™ Sure KO |
Compact TALEN™ |
| Learn more about TALEN™ basic | Learn more about TALEN™ Sure KO | Learn more about Compact TALEN™ | |
| Applications | Gene modification (e.g. gene tagging, nucleotide substitution) | Gene knock-out | Gene modification (e.g. gene tagging, nucleotide substitution) and gene knock-out in difficult to transfect cells |
| Level of validation |
No validation First human (validation in human cell lines) First mouse & rat (validation in mouse & rat lines) Premium (validation in customer's cell lines) |
No validation First human (validation in human cell lines) |
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| Deliverables |
2 TALEN™ |
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TALEN™ delivery timelines |
4 to 9 weeks* | ||
* additional 4 weeks for validation report
Benefits
Trust |
Reliable |
Guaranteed |
Highest chances of success for your gene editing projectCell engineering expertise since 1999 shared with our customers Dedicated Custom TALEN™ project support |
The best TALEN™design (hit and scaffold) with highest efficencyStrong R&D support for optimized TALEN™ design Bioinformatics expert support for proprietary TALEN™ Hit™ Software |
Your "custom-made" TALEN™ with rigorous quality control and validation to guarantee high DNA cutting activityValidation of sequence specific TALEN™ activity RVDs systematically sequenced after TALEN™ assembly |
Related products and services
Specific solutions for methylated DNA
Are you aware of any limitations using TAL Effector nuclease in your cell lines such as high methylation levels?
At Cellectis bioreserarch we have the solution! Learn more about our TALEN™ CpG to edit methylated DNA.
Custom TALEN™ project support
For any of your gene editing projects, we offer Custom TALEN™ project support, a comprehensive service to learn how to optimize your TALEN™ project and how to use your TALEN™ in the most efficient way. Dedicated project support managers will share with you their expertise and know-how to define the best Custom TALEN™ suited for your sepcific gene editing project.
Cell Line Customization services
Do you have any other gene editing projects in mind? Would you like to take advantage of our expertise to design your Custom TALEN™ and engineer your cell line of choice directly?
Please visit our Cell Line Customization services page.